The evolution of resistance to diseases, from infectious illnesses to cancers, poses a formidable challenge. Despite the expectation that resistance-conferring mutations would dwindle in the absence ...

EVOFLUx uses DNA methylation fluctuations as molecular barcodes to trace tumor evolution, offering insights into growth, treatment resistance, and prognosis. The method requires only bulk methylation ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for improving ...

Every multicellular creature - whether soaring through the skies, swimming in the ocean's depths or roaming the earth's surface - shares a common vulnerability: the uncontrolled growth of cells known ...

Cancer’s most catastrophic DNA damage has long looked like a crime scene without a culprit, with chromosomes shattered and ...

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few ...

For more than 80 years, men have been told that testosterone fuels prostate cancer. But a more nuanced picture has emerged ...

The authors created detailed 3D renderings of tumors from more than 2,000 individuals, with breast, colon, pancreatic, kidney and uterine cancers, among others. From these detailed atlases, the ...

George Butler receives funding from the Prostate Cancer Foundation and the US Department of Defense CDMRP/PCRP (HT9425-23-1-0157). Joanna Baker does not work for, consult, own shares in or receive ...

As part of its Speaking Out video series, CURE talked to Dr. Brian Keith McNeil, on behalf of ZERO Prostate Cancer, about navigating treatment option in prostate cancer. Advancements in prostate ...