DNA's iconic double helix does more than "just" store genetic information. Under certain conditions it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Insights could not only pave the way for new treatment strategies for genetic disorders, cancer and neurodegenerative diseases, but also enhance gene-editing technologies.

Study establishes for the first time that defective DNA repair may be the major driver of several clinical features associated with a subset of patients with 22q11.2 distal deletion syndrome ...

New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

The FDA has granted orphan drug designation (ODD) to LP-284, a next-generation acylfulvene small molecule, for the treatment of soft tissue sarcomas (STS). This is the third orphan designation for ...

There’s an old saying about a dollar waiting on a dime. In other words, a monumental endeavor may become stuck at some point if a key preliminary element remains unavailable. The saying could be ...

Plectonemes are the analog of the twisted tangles of telephone cords, and can form in DNA that is pulled through a nanoscale channel. They are called plectonemes. They are the analog of the twisted ...