An international team led by a University of Pittsburgh School of Medicine scientist has created a first-of-its-kind resource ...

Heart disease is still the number one cause of death among adults worldwide. High cholesterol levels are one contributor to heart disease.. | Genetics And Genomics ...

An international team led by a University of Pittsburgh School of Medicine scientist has created a first-of-its-kind resource ...

In 1985, the Nobel Prize in Physiology or Medicine was awarded to Michael Brown and Joseph Goldstein for identifying the receptor that clears LDL particles from the bloodstream. High blood levels of ...

Scientists have developed a groundbreaking genetic map. This resource identifies individuals at risk for high cholesterol and ...

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is highly expressed in adult hepatocytes. PCSK9 binds to and promotes the degradation of the low-density lipoprotein (LDL) receptor, thereby ...

Heart disease caused by damage to blood vessels is the leading cause of death worldwide. Arteries become clogged with fats and cholesterol when certain proteins in the body, known as lipoproteins, ...

Pittsburgh researchers develop a genetic tool that detects hidden risks for high LDL cholesterol, aiding early prevention of heart attacks and strokes.

Scientists at the University of Barcelona have unveiled a DNA-based therapy that dramatically lowers cholesterol by targeting ...

Alumni Endowed Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine RNA viruses use a ...

Robust efficacy data: ≥90% LDL-C reduction in non-human primates achieved within 48 hours of a single dose of EDIT-401; ≥90% LDL-C reduction in mice with high baseline LDL-C and reduced LDLR function ...