Researchers have changed the way to look at DNA. They show that DNA is much more than a linear sequence of building blocks; it has a 3D structure that influences the variation of human genome-wide ...

These sequences are extremely prone to mutations and rank among the most functionally important regions in the entire human ...

Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals.

Between any two people, there are likely to be at least 10 million differences in the genetic sequence that makes up their DNA. Most of these differences don't alter the way cells behave or cause ...

Proteins are like Spider-Man in the multiverse. The underlying story is the same: each building block of a protein is based on a three-letter DNA code. However, change one letter, and the same protein ...

Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

Explore the new AI model that links genetic mutations to disease outcomes, revolutionising genetic diagnosis and treatment.

Artificial intelligence is rapidly becoming medicine’s most powerful microscope, revealing patterns in human DNA that were ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

During development of the digestive system, a complex network of nerves forms around it, creating a "second brain"—the ...