The findings of this important study substantially advance our understanding of the transcription factors that can induce hair cell-like cells from human pluripotent stem cells. The presented evidence ...

The POU4F3-tdTomato hair cell reporter becomes visible after ∼3 days of reprogramming. Representative images were acquired at 0-, 3- or 7-days post-doxycycline treatment. Scale bar represents 200 µm.

Scientists from Nagoya University have developed a fast and safe method to create lung cells from skin-like fibroblasts – without using stem cells. This technique could allow for new regenerative ...

Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse embryonic fibroblasts without using stem cell technology. The AT2-like cells ...

The 2024 Chevy Silverado 1500 pickup is included in a new service update published by GM, which indicates some units are affected by a programming fault in the Brake System Control Module (BSCM). The ...

A team led by researchers has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other ...

A mature cell of one type can be turned into a mature cell of another type without the cell having to pass through an earlier stage of development. This is called direct reprogramming, a reliable but ...

Summary: Neural crest stem cells, a rare type found in skin and other tissues, are uniquely capable of reprogramming into different cell types, challenging the prevailing belief that any mature cell ...

Direct reprogramming has revolutionized the fields of stem cell biology and regenerative medicine. Targeted transdifferentiation of cells in situ holds significant promise in treating a large swathe ...

A collaboration between four MIT groups, led by principal investigators Laura L. Kiessling, Jeremiah A. Johnson, Alex K. Shalek, and Darrell J. Irvine, in conjunction with a group at Georgia Tech led ...

Researchers have used microRNA-based direct reprogramming to generate neurons from fibroblasts, providing new insights into late-onset Alzheimer’s disease. Aging is the most significant risk factor ...